Mechanism of Electrophilic Substitution in Quinoline and Isoquinoline
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چکیده
منابع مشابه
Lithiation and Electrophilic Substitution of Dimethyl Triazones.
The lithiation and electrophilic substitution of dimethyl triazones is described. Directed lithiation or tin-lithium exchange of dimethyl triazones afforded the corresponding dipole stabilized nucleophiles that were trapped with various electrophiles. Keto-triazone derivatives accessed by acylation of such nucleophiles were readily converted to the corresponding imidazolone heterocycles.
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Ab initio non-adiabatic dynamics is used to monitor the attack of CH3(+) to benzene. The results show that in the gas phase the reaction is ultrafast and is governed by a single electron transfer producing a radical pair.
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Protonation of the highly reactive 1:l intermediate produced in the reaction between triphenylphosphine and dimethyl acetylenedicarboxylate by 2- hydroxyacetophenone leads to vinyltriphenylphosphonium salt, which undergoes aromatic electrophilic substitution reaction with the conjugate base to produce compounds 4,5, and 6 in 1 : 1.2:0.5 ratios
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ژورنال
عنوان ژورنال: Australian Journal of Chemistry
سال: 1961
ISSN: 0004-9425
DOI: 10.1071/ch9610643